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    For Doctors

    Akkure provides precision insights which support Consultant-led, innovative care. Our genetic screening service is backed by Europe’s leading clinical grade screening services so you can trust that our genomics is supported by real science.

    What we offer?

    Whole Exome Sequencing not restricted to hotspots from samples processed according to accredited procedures.

    Genomics Screening resulting in a comprehensive medical report with interpretations of the findings and recommendations.

    Genetic Counseling Services to support your patient care and delivery of next steps.

    What genes do our screens cover?

    All of our Whole Exome tests include a Pharmagogenomics screen. In addition, our Disease Preventative Screens comprise genes that have been identified as risk genes. The list of genes incorporates recommendations of the American College of Medical Genetics and Genomics (ACMG). For all genes of the Disease Prevention Panel, the following holds true: A gene variant can cause a certain disease risk, and if so, there is a therapeutic action to address this risk.

    Pharmagogenomics Screen. ABCG2, CACNA1S, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4, CYP3A5, CYP4F2, DPYD, G6PD, HLA-A, HLA-B, IFNL3, MT-RNR1, NUDT15, POR, RYR1, SLCO1B1, TPMT, UGT1A1, VKORC1 

    Cancer Preventative Screen. APC, ATM, AXIN2, BAP1, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDC73, CDH1, CDKN2A, CHEK2, DICER1, EPCAM, FH, FLCN, KIT, MEN1, MET, MLH1, MSH2, MSH6, NF1, NF2, PALB2, PDGFRA, PMS2, POLD1, POLE, PTCH1, PTEN, RAD51C, RAD51D, RB1, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, SMARCB1, STK11, TMEM127, TP53, TSC1, TSC2, VHL, WT1

    Cardiovascular Preventative Screen. ACTA2, ACTC1, ACVRL1, ALPK3, BAG3, BMPR2, CALM1, CALM2, CALM3, CASQ2, COL3A1, DES, DSC2, DSG2, DSP, EMD, ENG, FBN1, FHL1, FLNC, GDF2, JUP, KCNH2, KCNK3, KCNQ1, LAMP2, LMNA, LOX, MYBPC3, MYH11, MYH7, MYL2, MYL3, MYLK, PKP2, PLN, PRKAG2, PRKG1, RBM20, RYR2, SCN5A, SMAD3, SMAD9, TBX4, TECRL, TGFB2, TGFBR1, TGFBR2, TMEM43, TNNC1, TNNI3, TNNT2, TPM1, TTN, TTR

    Thrombosis and Coagulation Disorders Preventaive Screen. ADAMTS13, F10, F11, F12, F13A1, F13B, F2, F5, F7, F8 (intronic inversions not covered), F9, GFI1B, GP1BA, GP1BB, GP6, GP9, HRG, ITGA2B, ITGB3, LMAN1, MCFD2, NBEAL2, PROC, PROS1, SERPINC1, SERPIND1, SERPINF2, VWF

    Iron and Copper Storage Disorders Preventative Screen. ATP7B, CP, GLRX5, HAMP, HFE, HJV, SLC40A1, TFR2, APOB, LDLR, LDLRAP1, PCSK9

    Glaucoma Preventative Screen. CYP1B1, MYOC

    Maignant Hyperthermia Preventative Screen. CACNA1S, RYR1

    Familial Diabetes Preventative Screen. GCK, HNF1A, HNF1B, HNF4A, PDX1

    Why test with Akkure

    Online DNA tests of the past decade or so tend to only examine and report on a small subset of the points within the genome, while Whole Exome Sequencing looks at the complete DNA contained in all of the 23,000 protein-coding genes.

    AKKURE’s medical grade genomic sequencing goes a step further, and even examines areas outside of these regions that have been linked to disease, providing an incredibly detailed and comprehensive picture of your patient’s genetic health.

    Our laboratory is certified by the International Organisation for Standardisation (ISO 15189:2012), whereas the majority of other online DNA tests are not. Essentially, traditional online DNA testing is cheap because it is less sophisticated and not nearly as exhaustive or comprehensive – the technology they use is suitable for producing interesting wellness reports and carrying out superficial genetic studies of popular interest, but not for medical testing.

    Testing with AKKURE is the genetic equivalent of a whole body MRI as opposed to an X-ray of a single region.

     

    Finally, along with the whole exome sequencing we also provide in depth pharmacogenomics reporting, which is the examination of an individual’s DNA in order to predict how they will respond to certain medications.

    Akkure Whole Exome sequencing and Preventative ScreeningOther online DNA tests
    Cancer gene testingCaptures mutations across all genes, reports in detail on 51 genes linked to various cancersTypically only reports on a small number of mutations across 2 genes linked to breast cancer
    Medical laboratory ISO certifiedYesNo
    Suitable for researchYesYes
    Suitable for clinical testingYesNo
    Avoids population biasYesNo
    Future proof - ability to report on harmful variants found in future researchYesNo
    Overlay other panels to report on diseasesYesNo
    In depth pharmagogenomics reportingYesNo
    Advice provided on appropriate action on finding potentially harmful mutationsYesNo
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